Drug interactions
Eszopiclone + Sufentanil sl
Severity: Major
Eszopiclone and Sufentanil sl: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedative-hypnotic with a sublingual opioid can cause profound sedation, respiratory depression, hypotension, coma and death.
What this interaction means in plain words
Eszopiclone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and GABA-A modulation.
What to do
Reserve for patients without alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Frequently asked questions
Can I take Eszopiclone with Sufentanil sl?
MediHelp rates the interaction as major. Eszopiclone and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedative-hypnotic with a sublingual opioid can cause profound sedation, respiratory depression, hypotension, coma and death.
How serious is the interaction between Eszopiclone and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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