Drug interactions
Ethambutol + Probenecid
Severity: Moderate
Ethambutol and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
What this interaction means in plain words
Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethambutol belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Ethambutol decreases renal tubular urate excretion, pharmacodynamically antagonizing the uricosuric action of probenecid.
What to do
Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Ethambutol
Frequently asked questions
Can I take Ethambutol with Probenecid?
MediHelp rates the interaction as moderate. Ethambutol and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can cause hyperuricemia or provoke gout. This opposes the urate-lowering effect of probenecid and may require adjustment of gout therapy.
How serious is the interaction between Ethambutol and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol treatment. Increase the uricosuric dose or switch to another urate-lowering agent if control is lost.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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