Drug interactions
Ethanol + Metaxalone
Severity: Moderate
Ethanol and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol enhances the sedation, dizziness and impaired judgment caused by metaxalone. This raises the risk of accidents, falls and, with heavy intake, significant CNS depression.
What this interaction means in plain words
Ethanol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of alcohol and metaxalone.
What to do
Advise patients to avoid alcohol while taking metaxalone and not to drive or operate machinery if they have consumed it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Ethanol with Metaxalone?
MediHelp rates the interaction as moderate. Ethanol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol enhances the sedation, dizziness and impaired judgment caused by metaxalone. This raises the risk of accidents, falls and, with heavy intake, significant CNS depression.
How serious is the interaction between Ethanol and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid alcohol while taking metaxalone and not to drive or operate machinery if they have consumed it.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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