Drug interactions
Ethanol + Ziprasidone
Severity: Moderate
Ethanol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol and ziprasidone both depress the CNS, so drinking can increase drowsiness, impair judgement and psychomotor skills, and worsen orthostatic hypotension. Alcohol may also worsen psychiatric illness and adherence.
What this interaction means in plain words
Ethanol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and vasodilatory hypotension.
What to do
Advise patients to avoid or minimize alcohol while taking ziprasidone. Counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Ethanol with Ziprasidone?
MediHelp rates the interaction as moderate. Ethanol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol and ziprasidone both depress the CNS, so drinking can increase drowsiness, impair judgement and psychomotor skills, and worsen orthostatic hypotension. Alcohol may also worsen psychiatric illness and adherence.
How serious is the interaction between Ethanol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid or minimize alcohol while taking ziprasidone. Counsel on driving and fall risk.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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