Drug interactions
Ethinyl estradiol-levonorgestrel + Leniolisib
Severity: Minor
Ethinyl estradiol-levonorgestrel and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP in vitro and may increase exposure to BCRP substrates, which could include ethinyl estradiol. The clinical relevance is uncertain and likely small.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
BCRP inhibition by leniolisib possibly increasing ethinyl estradiol exposure; clinical effect unconfirmed.
What to do
No routine action is needed; monitor for estrogen-related adverse effects. Leniolisib labeling also advises effective contraception during therapy because of fetal risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Leniolisib?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP in vitro and may increase exposure to BCRP substrates, which could include ethinyl estradiol. The clinical relevance is uncertain and likely small.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for estrogen-related adverse effects. Leniolisib labeling also advises effective contraception during therapy because of fetal risk.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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