Drug interactions
Ethinyl estradiol-levonorgestrel + Nicardipine
Severity: Minor
Ethinyl estradiol-levonorgestrel and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and could slightly raise nicardipine exposure. Nicardipine is itself a CYP3A4 substrate with a dose-related hypotensive effect, so any increase is likely small and manageable. Estrogens may also raise blood pressure in some women, working against antihypertensive therapy.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol may decrease nicardipine metabolism.
What to do
Monitor blood pressure and heart rate after starting or stopping the contraceptive and adjust the nicardipine dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Nicardipine?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and could slightly raise nicardipine exposure. Nicardipine is itself a CYP3A4 substrate with a dose-related hypotensive effect, so any increase is likely small and manageable. Estrogens may also raise blood pressure in some women, working against antihypertensive therapy.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or stopping the contraceptive and adjust the nicardipine dose as needed.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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