Drug interactions
Ethinyl estradiol-levonorgestrel + Quinidine
Severity: Minor
Ethinyl estradiol-levonorgestrel and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and could increase ethinyl estradiol exposure in theory. No clinically meaningful consequences are well documented, and the interaction is largely theoretical.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Possible inhibition of P-glycoprotein efflux, increasing absorption of ethinyl estradiol.
What to do
No routine action is required. Monitor for estrogenic adverse effects such as nausea or breast tenderness if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Quinidine?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine inhibits P-glycoprotein and could increase ethinyl estradiol exposure in theory. No clinically meaningful consequences are well documented, and the interaction is largely theoretical.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Monitor for estrogenic adverse effects such as nausea or breast tenderness if symptoms arise.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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