Drug interactions
Ethinyl estradiol-levonorgestrel + Ramelteon
Severity: Minor
Ethinyl estradiol-levonorgestrel and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor and may raise ramelteon levels. Ramelteon is mainly CYP1A2-metabolized, so exposure could increase with somnolence or dizziness, but clinical relevance is likely small.
What this interaction means in plain words
Ethinyl estradiol-levonorgestrel and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Ramelteon belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol reduces ramelteon clearance.
What to do
Monitor for excess daytime sedation and dizziness, and consider reducing or stopping ramelteon if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ethinyl estradiol-levonorgestrel with Ramelteon?
MediHelp rates the interaction as minor. Ethinyl estradiol-levonorgestrel and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP1A2 inhibitor and may raise ramelteon levels. Ramelteon is mainly CYP1A2-metabolized, so exposure could increase with somnolence or dizziness, but clinical relevance is likely small.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess daytime sedation and dizziness, and consider reducing or stopping ramelteon if they occur.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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