Drug interactions
Ethinyl estradiol-norgestimate + Lapatinib
Severity: Minor
Ethinyl estradiol-norgestimate and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and might slightly raise lapatinib exposure. Clinical relevance is likely low, though lapatinib can cause QT prolongation, diarrhea and hepatotoxicity.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated lapatinib metabolism.
What to do
No routine adjustment is needed; monitor liver tests and ECG as part of standard lapatinib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Lapatinib?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and might slightly raise lapatinib exposure. Clinical relevance is likely low, though lapatinib can cause QT prolongation, diarrhea and hepatotoxicity.
How serious is the interaction between Ethinyl estradiol-norgestimate and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor liver tests and ECG as part of standard lapatinib care.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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