Drug interactions
Ethinyl estradiol-norgestimate + Lemborexant
Severity: Minor
Ethinyl estradiol-norgestimate and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and may raise lemborexant levels, potentially increasing somnolence and next-day impairment.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition reduces lemborexant clearance.
What to do
Monitor for excessive sedation and next-morning impairment. Follow the lemborexant label for dose reduction with weak CYP3A4 inhibitors if effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Lemborexant?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and may raise lemborexant levels, potentially increasing somnolence and next-day impairment.
How serious is the interaction between Ethinyl estradiol-norgestimate and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and next-morning impairment. Follow the lemborexant label for dose reduction with weak CYP3A4 inhibitors if effects occur.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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