Drug interactions
Ethinyl estradiol-norgestimate + Lenacapavir
Severity: Moderate
Ethinyl estradiol-norgestimate and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor with a long persistence after subcutaneous dosing, so it may raise exposure to ethinyl estradiol and norgestimate for months. This could increase hormone-related adverse effects.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, decreasing the metabolism of ethinyl estradiol and norgestimate.
What to do
Monitor for estrogen-related adverse effects such as hypertension and thrombotic symptoms. Consider a lower-dose or non-oral contraceptive if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-norgestimate and Lenacapavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Lenacapavir?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor with a long persistence after subcutaneous dosing, so it may raise exposure to ethinyl estradiol and norgestimate for months. This could increase hormone-related adverse effects.
How serious is the interaction between Ethinyl estradiol-norgestimate and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects such as hypertension and thrombotic symptoms. Consider a lower-dose or non-oral contraceptive if effects occur.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
