Drug interactions
Ethinyl estradiol-norgestimate + Mexiletine
Severity: Moderate
Ethinyl estradiol-norgestimate and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise mexiletine concentrations. Mexiletine has a narrow therapeutic index, so higher levels could cause nausea, tremor, dizziness or arrhythmia.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Mexiletine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP1A2-mediated mexiletine metabolism.
What to do
Monitor for mexiletine adverse effects and consider checking plasma levels or adjusting the dose when the contraceptive is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Mexiletine?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethinyl estradiol is a weak CYP1A2 inhibitor and may modestly raise mexiletine concentrations. Mexiletine has a narrow therapeutic index, so higher levels could cause nausea, tremor, dizziness or arrhythmia.
How serious is the interaction between Ethinyl estradiol-norgestimate and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mexiletine adverse effects and consider checking plasma levels or adjusting the dose when the contraceptive is started or stopped.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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