Drug interactions
Ethinyl estradiol-norgestimate + Mifepristone
Severity: Moderate
Ethinyl estradiol-norgestimate and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone blocks progesterone receptors and can counteract the progestin effect of the contraceptive. Contraceptive reliability may be reduced around the time of use, and the pill may also interfere with the intended action of mifepristone.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-norgestimate belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism at the progesterone receptor.
What to do
Delay starting or resuming hormonal contraception per product guidance after mifepristone, and use a non-hormonal backup method meanwhile.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Mifepristone?
MediHelp rates the interaction as moderate. Ethinyl estradiol-norgestimate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone blocks progesterone receptors and can counteract the progestin effect of the contraceptive. Contraceptive reliability may be reduced around the time of use, and the pill may also interfere with the intended action of mifepristone.
How serious is the interaction between Ethinyl estradiol-norgestimate and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay starting or resuming hormonal contraception per product guidance after mifepristone, and use a non-hormonal backup method meanwhile.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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