Drug interactions
Ethinyl estradiol-norgestimate + Naratriptan
Severity: Minor
Ethinyl estradiol-norgestimate and Naratriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral contraceptives may slightly reduce naratriptan clearance, giving somewhat higher triptan exposure. Labeling data suggest the change is small and not clinically important in most patients.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Naratriptan belongs to Central Nervous System.
Why it happens
Oral contraceptives may modestly reduce naratriptan clearance, although the exact mechanism is not established.
What to do
No dose change is generally needed. Be aware that migraine with aura is a separate concern for estrogen-containing contraceptive use because of stroke risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Naratriptan?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Naratriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral contraceptives may slightly reduce naratriptan clearance, giving somewhat higher triptan exposure. Labeling data suggest the change is small and not clinically important in most patients.
How serious is the interaction between Ethinyl estradiol-norgestimate and Naratriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Be aware that migraine with aura is a separate concern for estrogen-containing contraceptive use because of stroke risk.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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