Drug interactions
Ethinyl estradiol-norgestimate + Nicardipine
Severity: Minor
Ethinyl estradiol-norgestimate and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol may modestly reduce CYP3A4 metabolism of nicardipine, potentially increasing its blood pressure-lowering effect. Nicardipine is also itself a CYP3A4 inhibitor, and the clinical significance of the combination is generally small.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ethinyl estradiol.
What to do
Monitor blood pressure and heart rate and adjust nicardipine if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Nicardipine?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol may modestly reduce CYP3A4 metabolism of nicardipine, potentially increasing its blood pressure-lowering effect. Nicardipine is also itself a CYP3A4 inhibitor, and the clinical significance of the combination is generally small.
How serious is the interaction between Ethinyl estradiol-norgestimate and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust nicardipine if hypotension or edema develops.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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