Drug interactions
Ethinyl estradiol-norgestimate + Ramelteon
Severity: Minor
Ethinyl estradiol-norgestimate and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is mainly metabolised by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor. Exposure to ramelteon may rise somewhat, causing greater daytime drowsiness or dizziness.
What this interaction means in plain words
Ethinyl estradiol-norgestimate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-norgestimate belongs to Endocrine; Ramelteon belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition reduces ramelteon clearance.
What to do
Monitor for excessive sedation and dizziness; reduce or stop ramelteon if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ethinyl estradiol-norgestimate with Ramelteon?
MediHelp rates the interaction as minor. Ethinyl estradiol-norgestimate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is mainly metabolised by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor. Exposure to ramelteon may rise somewhat, causing greater daytime drowsiness or dizziness.
How serious is the interaction between Ethinyl estradiol-norgestimate and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness; reduce or stop ramelteon if these occur.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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