Drug interactions
Ethinylestradiol + Ramelteon
Severity: Minor
Ethinylestradiol and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinylestradiol is a weak CYP1A2 inhibitor, and ramelteon is mainly metabolized by CYP1A2. Ramelteon exposure may be somewhat higher in users of estrogen-containing products, with more drowsiness possible.
What this interaction means in plain words
Ethinylestradiol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP1A2-mediated ramelteon metabolism.
What to do
No dose adjustment is usually needed; ask about excess morning drowsiness and reduce ramelteon dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ethinylestradiol with Ramelteon?
MediHelp rates the interaction as minor. Ethinylestradiol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinylestradiol is a weak CYP1A2 inhibitor, and ramelteon is mainly metabolized by CYP1A2. Ramelteon exposure may be somewhat higher in users of estrogen-containing products, with more drowsiness possible.
How serious is the interaction between Ethinylestradiol and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; ask about excess morning drowsiness and reduce ramelteon dose if it occurs.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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