Drug interactions
Ethiodized oil + Linagliptin-metformin
Severity: Major
Ethiodized oil and Linagliptin-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethiodized oil is an iodinated contrast agent; administration, especially intra-arterially (e.g. chemoembolization), may impair renal function and cause metformin accumulation. This increases the risk of lactic acidosis.
What this interaction means in plain words
Ethiodized oil and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Contrast-associated kidney injury reduces renal metformin clearance.
What to do
Hold metformin around the procedure in patients with eGFR below 30 or with acute kidney injury or intra-arterial dosing. Restart after renal function is confirmed stable about 48 hours later.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethiodized oil and Linagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Ethiodized oil with Linagliptin-metformin?
MediHelp rates the interaction as major. Ethiodized oil and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethiodized oil is an iodinated contrast agent; administration, especially intra-arterially (e.g. chemoembolization), may impair renal function and cause metformin accumulation. This increases the risk of lactic acidosis.
How serious is the interaction between Ethiodized oil and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around the procedure in patients with eGFR below 30 or with acute kidney injury or intra-arterial dosing. Restart after renal function is confirmed stable about 48 hours later.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
