Drug interactions
Ethiodized oil + Saxagliptin-metformin
Severity: Moderate
Ethiodized oil and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast media can cause acute kidney injury, and impaired renal function reduces metformin clearance. Accumulated metformin can lead to lactic acidosis, a rare but serious complication. Ethiodized oil is used mainly for lymphography and hysterosalpingography or intra-arterial chemoembolization, so systemic exposure and renal risk depend on the route and procedure.
What this interaction means in plain words
Ethiodized oil and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Contrast-associated reduction in renal function lowers metformin elimination, raising the risk of metformin accumulation and lactic acidosis.
What to do
Check eGFR before the procedure and withhold metformin in patients with eGFR below 30, with acute kidney injury, or undergoing intra-arterial studies with renal exposure. Re-assess renal function about 48 hours afterwards and restart metformin only if it is stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Ethiodized oil with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ethiodized oil and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast media can cause acute kidney injury, and impaired renal function reduces metformin clearance. Accumulated metformin can lead to lactic acidosis, a rare but serious complication. Ethiodized oil is used mainly for lymphography and hysterosalpingography or intra-arterial chemoembolization, so systemic exposure and renal risk depend on the route and procedure.
How serious is the interaction between Ethiodized oil and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check eGFR before the procedure and withhold metformin in patients with eGFR below 30, with acute kidney injury, or undergoing intra-arterial studies with renal exposure. Re-assess renal function about 48 hours afterwards and restart metformin only if it is stable.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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