Drug interactions
Ethosuximide + Pexidartinib
Severity: Moderate
Ethosuximide and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a moderate CYP3A4 inducer and may lower ethosuximide concentrations. Reduced levels could lead to breakthrough seizures.
What this interaction means in plain words
Ethosuximide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethosuximide belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Pexidartinib induces CYP3A4, accelerating ethosuximide metabolism.
What to do
Monitor seizure control and ethosuximide levels, and increase the ethosuximide dose if needed. Recheck levels after pexidartinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Ethosuximide with Pexidartinib?
MediHelp rates the interaction as moderate. Ethosuximide and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib is a moderate CYP3A4 inducer and may lower ethosuximide concentrations. Reduced levels could lead to breakthrough seizures.
How serious is the interaction between Ethosuximide and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and ethosuximide levels, and increase the ethosuximide dose if needed. Recheck levels after pexidartinib is stopped.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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