Drug interactions
Amiodarone + Pexidartinib
Severity: Major
Amiodarone and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib can cause serious liver injury, and amiodarone is also hepatotoxic while inhibiting CYP3A4 and raising pexidartinib exposure. The combination increases the risk of liver injury.
What this interaction means in plain words
Amiodarone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity plus CYP3A4 inhibition increasing pexidartinib levels.
What to do
Avoid the combination if possible. If needed, reduce the pexidartinib dose per labeling and monitor liver tests frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Amiodarone with Pexidartinib?
MediHelp rates the interaction as major. Amiodarone and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib can cause serious liver injury, and amiodarone is also hepatotoxic while inhibiting CYP3A4 and raising pexidartinib exposure. The combination increases the risk of liver injury.
How serious is the interaction between Amiodarone and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If needed, reduce the pexidartinib dose per labeling and monitor liver tests frequently.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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