Drug interactions
Aprepitant + Pexidartinib
Severity: Major
Aprepitant and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolized by CYP3A4, and aprepitant can increase its exposure. This raises the risk of pexidartinib toxicities, notably hepatotoxicity.
What this interaction means in plain words
Aprepitant and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of pexidartinib.
What to do
Avoid if possible; if needed, reduce the pexidartinib dose per labeling and monitor liver tests closely. Return to the previous dose after the inhibitor is stopped for about three half-lives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Aprepitant with Pexidartinib?
MediHelp rates the interaction as major. Aprepitant and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is metabolized by CYP3A4, and aprepitant can increase its exposure. This raises the risk of pexidartinib toxicities, notably hepatotoxicity.
How serious is the interaction between Aprepitant and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, reduce the pexidartinib dose per labeling and monitor liver tests closely. Return to the previous dose after the inhibitor is stopped for about three half-lives.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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