Drug interactions
Ethosuximide + Ustekinumab
Severity: Minor
Ethosuximide and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethosuximide is metabolized largely by CYP3A4. Ustekinumab may theoretically alter its clearance by reversing inflammatory CYP suppression, but this is unlikely to be significant.
What this interaction means in plain words
Ethosuximide and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethosuximide belongs to Central Nervous System; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Possible normalization of CYP expression after cytokine blockade.
What to do
Monitor seizure control and consider ethosuximide levels if ustekinumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Frequently asked questions
Can I take Ethosuximide with Ustekinumab?
MediHelp rates the interaction as minor. Ethosuximide and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethosuximide is metabolized largely by CYP3A4. Ustekinumab may theoretically alter its clearance by reversing inflammatory CYP suppression, but this is unlikely to be significant.
How serious is the interaction between Ethosuximide and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and consider ethosuximide levels if ustekinumab is started or stopped.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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