Drug interactions
Ethotoin + Felodipine
Severity: Moderate
Ethotoin and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is a hydantoin anticonvulsant related to phenytoin and may lower felodipine concentrations. This could lead to reduced antihypertensive or antianginal effect.
What this interaction means in plain words
Ethotoin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable induction of CYP3A4 increases felodipine metabolism, extrapolated from phenytoin.
What to do
Monitor blood pressure and angina control and increase the felodipine dose if needed. Consider an alternative antihypertensive class if response remains poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Ethotoin with Felodipine?
MediHelp rates the interaction as moderate. Ethotoin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin is a hydantoin anticonvulsant related to phenytoin and may lower felodipine concentrations. This could lead to reduced antihypertensive or antianginal effect.
How serious is the interaction between Ethotoin and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and angina control and increase the felodipine dose if needed. Consider an alternative antihypertensive class if response remains poor.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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