Drug interactions
Ethotoin + Metyrapone
Severity: Moderate
Ethotoin and Metyrapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is a hydantoin anticonvulsant and may induce hepatic enzymes, as phenytoin does. This could lower metyrapone exposure and weaken its inhibition of cortisol synthesis. The effect is predicted from related drugs rather than well documented for ethotoin.
What this interaction means in plain words
Ethotoin and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable induction of hepatic drug-metabolizing enzymes by the hydantoin, increasing metyrapone clearance.
What to do
Monitor serum cortisol and 11-deoxycortisol response, and increase the metyrapone dose if control of cortisol is inadequate. Reassess the dose if ethotoin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Ethotoin with Metyrapone?
MediHelp rates the interaction as moderate. Ethotoin and Metyrapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin is a hydantoin anticonvulsant and may induce hepatic enzymes, as phenytoin does. This could lower metyrapone exposure and weaken its inhibition of cortisol synthesis. The effect is predicted from related drugs rather than well documented for ethotoin.
How serious is the interaction between Ethotoin and Metyrapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum cortisol and 11-deoxycortisol response, and increase the metyrapone dose if control of cortisol is inadequate. Reassess the dose if ethotoin is stopped.
What other medicines interact with Metyrapone?
MediHelp also lists interactions of Metyrapone with, for example, Pacritinib, Budesonide, Cortisone. The full list is on the Metyrapone page.
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