Drug interactions
Ethotoin + Secobarbital
Severity: Moderate
Ethotoin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower ethotoin concentrations, potentially reducing seizure control. Barbiturates also have variable effects on hydantoins, so the direction of change is not always predictable.
What this interaction means in plain words
Ethotoin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate enzyme induction may increase hepatic metabolism of ethotoin; the exact pathway is not well established.
What to do
Monitor seizure control and ethotoin levels where available when starting or stopping secobarbital. Adjust the ethotoin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Ethotoin with Secobarbital?
MediHelp rates the interaction as moderate. Ethotoin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower ethotoin concentrations, potentially reducing seizure control. Barbiturates also have variable effects on hydantoins, so the direction of change is not always predictable.
How serious is the interaction between Ethotoin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and ethotoin levels where available when starting or stopping secobarbital. Adjust the ethotoin dose accordingly.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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