Drug interactions
Ethotoin + Tolazamide
Severity: Minor
Ethotoin and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolazamide may displace ethotoin from plasma proteins, temporarily raising the free fraction of the anticonvulsant. The clinical effect is likely small because the displaced drug is redistributed and cleared.
What this interaction means in plain words
Ethotoin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for plasma protein binding sites.
What to do
Monitor for signs of phenytoin-like toxicity such as ataxia or nystagmus when starting tolazamide. Check ethotoin levels if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ethotoin with Tolazamide?
MediHelp rates the interaction as minor. Ethotoin and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolazamide may displace ethotoin from plasma proteins, temporarily raising the free fraction of the anticonvulsant. The clinical effect is likely small because the displaced drug is redistributed and cleared.
How serious is the interaction between Ethotoin and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of phenytoin-like toxicity such as ataxia or nystagmus when starting tolazamide. Check ethotoin levels if symptoms develop.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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