Drug interactions
Ethotoin + Tolbutamide
Severity: Minor
Ethotoin and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydantoin anticonvulsants are highly protein bound and may be displaced by or compete with sulfonylureas, and they can reduce insulin release and raise glucose. Net effects on tolbutamide control and ethotoin levels are variable and usually small.
What this interaction means in plain words
Ethotoin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for plasma protein binding plus possible hydantoin-related inhibition of insulin secretion.
What to do
Monitor blood glucose and signs of ethotoin toxicity or loss of seizure control when the combination is started or changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Ethotoin with Tolbutamide?
MediHelp rates the interaction as minor. Ethotoin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydantoin anticonvulsants are highly protein bound and may be displaced by or compete with sulfonylureas, and they can reduce insulin release and raise glucose. Net effects on tolbutamide control and ethotoin levels are variable and usually small.
How serious is the interaction between Ethotoin and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and signs of ethotoin toxicity or loss of seizure control when the combination is started or changed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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