Drug interactions
Etodolac + Feverfew
Severity: Moderate
Etodolac and Feverfew: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has antiplatelet activity in laboratory studies and may add to the platelet inhibition and gastrointestinal bleeding risk of etodolac. Clinical data are limited, so the effect is largely predicted.
What this interaction means in plain words
Etodolac and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet function (feverfew inhibits platelet aggregation; etodolac inhibits cyclooxygenase-dependent platelet activity).
What to do
Ask patients about herbal use and advise against feverfew while on regular etodolac. Monitor for bruising, melena or other bleeding if it is continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Feverfew?
MediHelp rates the interaction as moderate. Etodolac and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has antiplatelet activity in laboratory studies and may add to the platelet inhibition and gastrointestinal bleeding risk of etodolac. Clinical data are limited, so the effect is largely predicted.
How serious is the interaction between Etodolac and Feverfew?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and advise against feverfew while on regular etodolac. Monitor for bruising, melena or other bleeding if it is continued.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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