Drug interactions
Etodolac + Fish oil triglycerides
Severity: Moderate
Etodolac and Fish oil triglycerides: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids can modestly prolong bleeding time, and with an NSAID such as etodolac the bleeding tendency may be additive. The clinical significance at usual doses is generally small but matters in patients with other bleeding risk factors.
What this interaction means in plain words
Etodolac and Fish oil triglycerides can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function: omega-3 fatty acids reduce platelet aggregation and etodolac inhibits platelet cyclooxygenase.
What to do
Monitor for signs of bleeding, particularly in patients also taking anticoagulants or antiplatelets or with GI ulcer history. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Fish oil triglycerides?
MediHelp rates the interaction as moderate. Etodolac and Fish oil triglycerides can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids can modestly prolong bleeding time, and with an NSAID such as etodolac the bleeding tendency may be additive. The clinical significance at usual doses is generally small but matters in patients with other bleeding risk factors.
How serious is the interaction between Etodolac and Fish oil triglycerides?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly in patients also taking anticoagulants or antiplatelets or with GI ulcer history. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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