Drug interactions
Etodolac + Ginkgo biloba
Severity: Moderate
Etodolac and Ginkgo biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo has been linked to case reports of spontaneous bleeding and may inhibit platelet activating factor. Combined with etodolac, the risk of bleeding, especially gastrointestinal, may be increased.
What this interaction means in plain words
Etodolac and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: ginkgolides antagonize platelet-activating factor while etodolac inhibits cyclooxygenase.
What to do
Advise avoiding ginkgo during regular NSAID therapy, and monitor for bleeding, bruising or black stools if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Ginkgo biloba?
MediHelp rates the interaction as moderate. Etodolac and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo has been linked to case reports of spontaneous bleeding and may inhibit platelet activating factor. Combined with etodolac, the risk of bleeding, especially gastrointestinal, may be increased.
How serious is the interaction between Etodolac and Ginkgo biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding ginkgo during regular NSAID therapy, and monitor for bleeding, bruising or black stools if used.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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