Drug interactions
Etodolac + Glibenclamide
Severity: Moderate
Etodolac and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate sulfonylurea effects and occasionally lead to hypoglycemia. The effect is inconsistent and appears modest with etodolac.
What this interaction means in plain words
Etodolac and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Glibenclamide belongs to Endocrine.
Why it happens
Possible protein-binding displacement and reduced renal clearance; the mechanism is not firmly established.
What to do
Monitor blood glucose when etodolac is started or stopped and counsel on hypoglycemia symptoms. Reduce the glyburide dose if low glucose occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Etodolac with Glibenclamide?
MediHelp rates the interaction as moderate. Etodolac and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate sulfonylurea effects and occasionally lead to hypoglycemia. The effect is inconsistent and appears modest with etodolac.
How serious is the interaction between Etodolac and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when etodolac is started or stopped and counsel on hypoglycemia symptoms. Reduce the glyburide dose if low glucose occurs.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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