Drug interactions
Etodolac + Hydrocortisone
Severity: Moderate
Etodolac and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a systemic corticosteroid with an NSAID raises the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with high doses, with prolonged use, or when anticoagulants are also given.
What this interaction means in plain words
Etodolac and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury: NSAIDs inhibit protective prostaglandin synthesis while corticosteroids impair mucosal healing.
What to do
Use the lowest effective doses for the shortest duration and consider adding a proton pump inhibitor in at-risk patients. Counsel patients to report black stools, hematemesis or epigastric pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Hydrocortisone?
MediHelp rates the interaction as moderate. Etodolac and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a systemic corticosteroid with an NSAID raises the risk of gastric and duodenal ulceration and gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients, with high doses, with prolonged use, or when anticoagulants are also given.
How serious is the interaction between Etodolac and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider adding a proton pump inhibitor in at-risk patients. Counsel patients to report black stools, hematemesis or epigastric pain.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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