Drug interactions
Etodolac + Icosapent
Severity: Moderate
Etodolac and Icosapent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may slightly prolong bleeding time, and with an NSAID like etodolac the risk of bleeding may be increased. Clinical bleeding events are uncommon but more likely with other hemostasis-affecting drugs.
What this interaction means in plain words
Etodolac and Icosapent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function from EPA-mediated reduced aggregation and NSAID cyclooxygenase inhibition.
What to do
Monitor for bleeding signs, especially with prior GI bleeding or additional anticoagulant or antiplatelet therapy. Reassess the need for NSAID therapy periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Icosapent?
MediHelp rates the interaction as moderate. Etodolac and Icosapent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl may slightly prolong bleeding time, and with an NSAID like etodolac the risk of bleeding may be increased. Clinical bleeding events are uncommon but more likely with other hemostasis-affecting drugs.
How serious is the interaction between Etodolac and Icosapent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs, especially with prior GI bleeding or additional anticoagulant or antiplatelet therapy. Reassess the need for NSAID therapy periodically.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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