Drug interactions
Etodolac + Indapamide
Severity: Moderate
Etodolac and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of indapamide and, with volume depletion, may impair renal function.
What this interaction means in plain words
Etodolac and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins leads to sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure and renal function, keep the patient well hydrated, and use the lowest effective etodolac dose briefly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Indapamide
Frequently asked questions
Can I take Etodolac with Indapamide?
MediHelp rates the interaction as moderate. Etodolac and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of indapamide and, with volume depletion, may impair renal function.
How serious is the interaction between Etodolac and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function, keep the patient well hydrated, and use the lowest effective etodolac dose briefly.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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