Drug interactions
Etodolac + Mipomersen
Severity: Moderate
Etodolac and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can raise liver transaminases and cause hepatic fat accumulation, and NSAIDs including etodolac can occasionally cause liver injury. Using them together could increase the risk of hepatotoxicity.
What this interaction means in plain words
Etodolac and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Stop or reduce therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Mipomersen?
MediHelp rates the interaction as moderate. Etodolac and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can raise liver transaminases and cause hepatic fat accumulation, and NSAIDs including etodolac can occasionally cause liver injury. Using them together could increase the risk of hepatotoxicity.
How serious is the interaction between Etodolac and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Stop or reduce therapy if transaminases rise significantly.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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