Drug interactions
Etodolac + Mycophenolate
Severity: Moderate
Etodolac and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac and mycophenolic acid glucuronide are both organic anions, so competition for renal tubular secretion may increase exposure to either. NSAIDs can also reduce renal function and worsen gastrointestinal toxicity in transplant patients.
What this interaction means in plain words
Etodolac and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of acidic drugs and metabolites, with NSAID-related renal and GI effects adding to toxicity.
What to do
Monitor renal function, blood counts and signs of mycophenolate toxicity such as GI upset and myelosuppression. Prefer an alternative analgesic like paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Mycophenolate?
MediHelp rates the interaction as moderate. Etodolac and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac and mycophenolic acid glucuronide are both organic anions, so competition for renal tubular secretion may increase exposure to either. NSAIDs can also reduce renal function and worsen gastrointestinal toxicity in transplant patients.
How serious is the interaction between Etodolac and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and signs of mycophenolate toxicity such as GI upset and myelosuppression. Prefer an alternative analgesic like paracetamol where possible.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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