Drug interactions
Etodolac + Nefazodone
Severity: Moderate
Etodolac and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antidepressants that block serotonin reuptake impair platelet function, and with NSAIDs the risk of gastrointestinal bleeding is increased. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is probably lower but still plausible.
What this interaction means in plain words
Etodolac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from reduced platelet serotonin uptake and NSAID inhibition of platelet cyclooxygenase with gastric mucosal injury.
What to do
Monitor for GI bleeding and consider gastroprotection in older patients or those with ulcer history. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Nefazodone?
MediHelp rates the interaction as moderate. Etodolac and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antidepressants that block serotonin reuptake impair platelet function, and with NSAIDs the risk of gastrointestinal bleeding is increased. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is probably lower but still plausible.
How serious is the interaction between Etodolac and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider gastroprotection in older patients or those with ulcer history. Use the lowest effective NSAID dose.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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