Drug interactions
Etodolac + Norepinephrine
Severity: Moderate
Etodolac and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine can reduce renal blood flow and NSAIDs further impair renal prostaglandin-dependent perfusion, so kidney injury risk may rise in critically ill patients. The potassium effects oppose each other and are of little practical importance.
What this interaction means in plain words
Etodolac and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal vasoconstriction: catecholamine vasoconstriction combined with loss of vasodilatory prostaglandins from NSAID use.
What to do
Avoid NSAIDs in patients needing vasopressor support when possible. Monitor urine output and serum creatinine if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Norepinephrine?
MediHelp rates the interaction as moderate. Etodolac and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine can reduce renal blood flow and NSAIDs further impair renal prostaglandin-dependent perfusion, so kidney injury risk may rise in critically ill patients. The potassium effects oppose each other and are of little practical importance.
How serious is the interaction between Etodolac and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs in patients needing vasopressor support when possible. Monitor urine output and serum creatinine if combined.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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