Drug interactions
Etodolac + Pau d'arco
Severity: Minor
Etodolac and Pau d'arco: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pau d'arco contains naphthoquinones such as lapachol, which can interfere with vitamin K-dependent clotting and may increase bleeding tendency. With etodolac, this could add to bleeding risk, though data are very limited.
What this interaction means in plain words
Etodolac and Pau d'arco have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible anticoagulant effect from lapachol (vitamin K antagonism) added to NSAID platelet inhibition; poorly characterized.
What to do
Advise avoiding pau d'arco products and report any unusual bleeding or bruising.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Pau d'arco?
MediHelp rates the interaction as minor. Etodolac and Pau d'arco have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pau d'arco contains naphthoquinones such as lapachol, which can interfere with vitamin K-dependent clotting and may increase bleeding tendency. With etodolac, this could add to bleeding risk, though data are very limited.
How serious is the interaction between Etodolac and Pau d'arco?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding pau d'arco products and report any unusual bleeding or bruising.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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