Drug interactions
Etodolac + Phenindione
Severity: Major
Etodolac and Phenindione: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac impairs platelet function and can injure the gastric mucosa, so combining it with the vitamin K antagonist phenindione raises the risk of clinically significant bleeding, particularly from the gastrointestinal tract. The anticoagulant effect itself may also be modestly altered.
What this interaction means in plain words
Etodolac and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment through NSAID platelet inhibition and mucosal injury plus vitamin K antagonism.
What to do
Avoid the combination where possible and use paracetamol or another alternative for analgesia. If it is unavoidable, monitor INR and signs of bleeding closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Phenindione?
MediHelp rates the interaction as major. Etodolac and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac impairs platelet function and can injure the gastric mucosa, so combining it with the vitamin K antagonist phenindione raises the risk of clinically significant bleeding, particularly from the gastrointestinal tract. The anticoagulant effect itself may also be modestly altered.
How serious is the interaction between Etodolac and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol or another alternative for analgesia. If it is unavoidable, monitor INR and signs of bleeding closely and consider gastroprotection.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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