Drug interactions
Etodolac + Phenoxybenzamine
Severity: Minor
Etodolac and Phenoxybenzamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine is an alpha-blocker whose vasodilatory effects may be partly offset by NSAIDs reducing prostaglandin synthesis. Documented clinical relevance is minimal.
What this interaction means in plain words
Etodolac and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism from NSAID-mediated reduction in vasodilatory prostaglandins and fluid retention.
What to do
Monitor blood pressure and clinical response when starting or stopping etodolac, and adjust phenoxybenzamine dosing if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Phenoxybenzamine?
MediHelp rates the interaction as minor. Etodolac and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenoxybenzamine is an alpha-blocker whose vasodilatory effects may be partly offset by NSAIDs reducing prostaglandin synthesis. Documented clinical relevance is minimal.
How serious is the interaction between Etodolac and Phenoxybenzamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and clinical response when starting or stopping etodolac, and adjust phenoxybenzamine dosing if needed.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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