Drug interactions
Etodolac + Pindolol
Severity: Moderate
Etodolac and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can blunt the blood pressure lowering effect of beta-blockers such as pindolol. Loss of blood pressure control may become apparent after more than a week of continuous NSAID therapy.
What this interaction means in plain words
Etodolac and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit renal and vascular prostaglandin synthesis, causing sodium and fluid retention and vasoconstriction that oppose the antihypertensive effect.
What to do
Monitor blood pressure when etodolac is used for more than a few days with pindolol. Use the lowest effective NSAID dose for the shortest time, and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Pindolol?
MediHelp rates the interaction as moderate. Etodolac and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can blunt the blood pressure lowering effect of beta-blockers such as pindolol. Loss of blood pressure control may become apparent after more than a week of continuous NSAID therapy.
How serious is the interaction between Etodolac and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when etodolac is used for more than a few days with pindolol. Use the lowest effective NSAID dose for the shortest time, and adjust antihypertensive therapy if control is lost.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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