Drug interactions
Etodolac + Quinapril
Severity: Moderate
Etodolac and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
What this interaction means in plain words
Etodolac and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, counteracting ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Quinapril?
MediHelp rates the interaction as moderate. Etodolac and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
How serious is the interaction between Etodolac and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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