Drug interactions
Etodolac + Reteplase
Severity: Major
Etodolac and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thrombolytics such as reteplase carry a high bleeding risk, and NSAIDs that impair platelet function may increase it further. Hemorrhage including intracranial or gastrointestinal bleeding is the concern.
What this interaction means in plain words
Etodolac and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Reteplase activates plasminogen to dissolve clots while etodolac inhibits platelet function and can injure the gastric mucosa, producing additive bleeding risk.
What to do
Review recent NSAID use before thrombolysis and avoid starting NSAIDs around it. Monitor closely for bleeding after administration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Reteplase?
MediHelp rates the interaction as major. Etodolac and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thrombolytics such as reteplase carry a high bleeding risk, and NSAIDs that impair platelet function may increase it further. Hemorrhage including intracranial or gastrointestinal bleeding is the concern.
How serious is the interaction between Etodolac and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review recent NSAID use before thrombolysis and avoid starting NSAIDs around it. Monitor closely for bleeding after administration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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