Drug interactions
Etodolac + Salicylates
Severity: Moderate
Etodolac and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining etodolac with a non-acetylated salicylate adds to NSAID-type adverse effects including gastrointestinal irritation, renal effects and possibly bleeding. It offers no extra benefit and increases toxicity.
What this interaction means in plain words
Etodolac and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both drugs inhibit prostaglandin synthesis, giving additive gastrointestinal, renal and platelet effects.
What to do
Avoid using two NSAID-type drugs together. If unavoidable, monitor for gastrointestinal bleeding and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Salicylates?
MediHelp rates the interaction as moderate. Etodolac and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining etodolac with a non-acetylated salicylate adds to NSAID-type adverse effects including gastrointestinal irritation, renal effects and possibly bleeding. It offers no extra benefit and increases toxicity.
How serious is the interaction between Etodolac and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAID-type drugs together. If unavoidable, monitor for gastrointestinal bleeding and renal function.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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