Drug interactions
Etodolac + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Etodolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs can reduce renal perfusion in volume-depleted patients. The combination may increase the risk of acute kidney injury.
What this interaction means in plain words
Etodolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from the bowel preparation combined with NSAID inhibition of renal prostaglandins impairs renal perfusion.
What to do
Hold etodolac on the day of bowel preparation where feasible and ensure adequate fluid intake. Monitor renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Etodolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs can reduce renal perfusion in volume-depleted patients. The combination may increase the risk of acute kidney injury.
How serious is the interaction between Etodolac and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold etodolac on the day of bowel preparation where feasible and ensure adequate fluid intake. Monitor renal function and electrolytes in high-risk patients.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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