Drug interactions
Etodolac + Sulfasalazine
Severity: Minor
Etodolac and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal upset, and sulfasalazine contains a salicylate moiety, so combining them may add to GI and renal adverse effects. Clinically significant interaction is generally modest.
What this interaction means in plain words
Etodolac and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive effects on prostaglandin-related gastric and renal function; no major pharmacokinetic interaction is established.
What to do
Monitor for gastrointestinal symptoms and renal function with long-term combined use, and take etodolac with food.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Sulfasalazine?
MediHelp rates the interaction as minor. Etodolac and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause gastrointestinal upset, and sulfasalazine contains a salicylate moiety, so combining them may add to GI and renal adverse effects. Clinically significant interaction is generally modest.
How serious is the interaction between Etodolac and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal symptoms and renal function with long-term combined use, and take etodolac with food.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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