Drug interactions
Etodolac + Tenofovir df
Severity: Moderate
Etodolac and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney, and NSAIDs such as etodolac can reduce renal perfusion. Together they may increase the risk of tenofovir-associated kidney injury, particularly with high or repeated NSAID dosing or pre-existing renal risk factors.
What this interaction means in plain words
Etodolac and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion adds to tenofovir tubular toxicity, with possible competition for renal elimination.
What to do
Prefer non-NSAID analgesics such as paracetamol. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Tenofovir df?
MediHelp rates the interaction as moderate. Etodolac and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by the kidney, and NSAIDs such as etodolac can reduce renal perfusion. Together they may increase the risk of tenofovir-associated kidney injury, particularly with high or repeated NSAID dosing or pre-existing renal risk factors.
How serious is the interaction between Etodolac and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-NSAID analgesics such as paracetamol. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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