Drug interactions
Etodolac + Ticarcillin
Severity: Moderate
Etodolac and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function at high doses, and NSAIDs also affect platelets and may reduce renal clearance of penicillins. The combination may modestly increase bleeding risk.
What this interaction means in plain words
Etodolac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from ticarcillin and NSAID COX-1 inhibition; NSAIDs may also reduce tubular secretion of penicillins.
What to do
Monitor for bleeding and bruising during high-dose ticarcillin therapy with etodolac, and check renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Ticarcillin?
MediHelp rates the interaction as moderate. Etodolac and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can impair platelet function at high doses, and NSAIDs also affect platelets and may reduce renal clearance of penicillins. The combination may modestly increase bleeding risk.
How serious is the interaction between Etodolac and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising during high-dose ticarcillin therapy with etodolac, and check renal function in at-risk patients.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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